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Abbreviations AD: Alzheimer's disease AGBL4: ATP/GTP binding protein like 4 BAX: Bcl-2-like protein 4 Bcl2: B-cell lymphoma 2 BDNF: Brain-derived neurotrophic factor CNS: Central nervous system CREB: CAMP response element-binding protein DMEM: Dulbecco's modified eagle medium FBS: Fetal bovine serum GAP43: Growth associated protein 43 GIP: Glucose-dependent insulinotropic polypeptide GLP1-RAs: Glucagon-like peptide 1 receptor agonists GLUT1: Glucose transporter 1 GLUT3: Glucose transporter 3 GLUT4: Glucose transporter 4 HG: High glucose Ki-67: Antigen Kiel 67 MAP2: Microtubule-associated protein 2 NG: Normal glucose pAkt: Phospho protein kinase B PBS: Phosphate-buffered saline SHSY5Y: Neuroblastoma cell line SORBS1: Sorbin and SH3 containing domain T2DM: Type 2 diabetes mellitus TIR: Tirzepatide TrisHCl: Tris hydrochloride NaCl: Sodium chloride NaF: Sodium fluoride PMSF: Phenylmethylsulfonyl fluoride SDS-PAGE: Sodium dodecyl sulphatepolyacrylamide gel electrophoresis TBS: Tris-buffered saline References Ramachandran AK, Das S, Joseph A, Shenoy GG, Alex AT, Mudgal J

This oxidative stress is particularly damaging because of METHs effects on dopamine, which undergoes autoxidation, leading to the generation of dopamine quinones and ROS (Figure 1)

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