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Obesity is a multifaceted disease that contributes directly and indirectly to atherosclerotic CVD, heart failure, atrial fibrillation and multiple CVD risk factors, including dyslipidaemia, type 2 diabetes, hypertension and sleep disorders (Figure)

Global DNA methylation (5-mC) level Levels of 5-methyl-2-deoxycytidine (5-mC) were assessed in liver tissue and cultured cells using the 5-mC DNA ELISA Kit (Zymo Research, Irvine, CA)

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