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Richard Looney and his research team have previously identified bone marrow mesenchymal stem cells (BM-MSC) from patients with systemic lupus erythmatosis (SLE) that exhibit signs of senescence

This widespread distribution has prompted researchers to investigate whether GLP-1 agonists might influence mental health conditions such as depression

When oxidative stress (e.g., H 2 O 2 treatment) leads to an increase in mitochondrial membrane permeability, mt-dsRNA leaks into the cytoplasm through voltage-dependent anion channels (VDAC) to form a pool of stress granule-associated free dsRNA [166]