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10.3389/fimmu.2016.00238 38 SubbianS.PandeyR.SoteropoulosP.RodriguezG

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105, 106, 107, 108, 109, 110, 111 Osteosarcomatous metaplasia in a malignant melanoma may be the sequela of an alteration in benign stromal fibroblasts as a host response to the tumor, or it could represent a divergent differentiation pattern, whereby melanoma cells acquire the machinery necessary for the production of malignant osteoid