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The vitamin supplements, but not the placebo significantly reduced all 4 metabolite concentrations (methylmalonic acid, homocysteine, 2-methylcitric acid and cystathionine)

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The overall heterogeneity for renal outcome was I 2 = 42.3% (95% uncertainty intervals, 0 and 68.0%) (moderate) (Additional file 1: Table S3) with no evidence of publication bias

Adv Nutr (2018) 9:81323