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MOTS-c is a mitochondrial-derived peptide that activates AMPK, the same metabolic switch exercise and fasting flip, improving insulin sensitivity, mitochondrial function, and metabolic flexibility

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Campos JC, Marchesi Bozi LH, Krum B, Grassmann Bechara LR, Ferreira ND, Arini GS, Albuquerque RP, Traa A, Ogawa T, van der Bliek AM, et al