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The Fc fusion increases the molecular weight to approximately 60 kDa, thereby reducing renal clearance

stiffness and resistance to limb movement caused by increased muscle tone and/ gait and posture disturbances such as festination (rapid shuffling steps and a forward-flexed posture when walking), speech and swallowing disturbances including voice disorders, masklike face expression or small handwriting, although the range of possible motor problems that can appear is large

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Several cross-sectional studies have suggested that MMA is a potential risk factor for cardiovascular disease (CVD), although small sample sizes may have limited their effectiveness [24, 25]