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The sections below synthesize current evidence with cautious, hypothesis-driven language, emphasizing where data are strongest and where additional experiments are needed

High levels of oxidative stress can disrupt sleep, while poor sleep can deplete glutathione

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Akin to several well-established post-translational modification (PTM) processes, e.g., phosphorylation, acetylation, and methylation, S -glutathionylation has recently been determined to play an important role in regulating protein function