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Therapeutic efficacy of L-ornithineLaspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebocontrolled, doubleblind study

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When mitochondrial function is impaired, enzyme complex IV in the inner mitochondrial membrane fails to produce water as it should, resulting in the production of O 2 -, which subsequently convert into OH and H 2 O 2

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When the cellular environment is under oxidative stress, Fe 3+ acts as a catalyst to drive the non-enzymatic oxidation of dopamine, leading to the formation of dopamine-quinone derivatives that can bind iron to form iron-dopamine-quinone complexes

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