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Beyond pancreatic effects, tirzepatide acts on receptors in the central nervous system to reduce appetite and food intake, contributing to the weight loss observed in clinical trials

Neurosurgery 85, 454465

In neurons of the substantia nigra, there is a sex difference in the response to GABA agonist, with a depolarizing effect maintained in males while females have the more mature hyperpolarizing response

Questions to ask your healthcare provider Ask why a specific drug class was chosen for you

It also inhibits SREBP-1c activity, limiting lipogenesis

Results were considered statistically significant when the p-value was 0.05 for all tests