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These residues are located within the upper and central regions of the TM2 and TM3 bundle and have been recurrently associated with ligand recognition in active-state GLP-1R structures (Zhao et al., 2020)

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Research suggests that the dual receptor action may make this class of drugs more effective at promoting weight loss than other GLP-1s

But a follow-up 2021 study, known as STEP 4, showed that within 48 weeks of no longer taking semaglutide, participants regained approximately two-thirds of their prior weight loss, while those who remained on GLP-1 drug therapy continued to lose weight

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Spit KA, et al