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This finding was sustained at 12 months of follow-up, according to the study, which analyzed more than 18,000 patients with obesity, both with and without Type 2 diabetes

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The Steno-2 study, a long-term prospective trial with a mean follow-up of 21 years, demonstrated that early intensive multifactorial therapy, including lifestyle interventions and simultaneous pharmacological management of hyperglycemia, dyslipidemia, hypertension, and microalbuminuria, resulted in a 70% reduction in the risk of hospitalization for HF

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