The warnings and precautions section covers acute pancreatitis, diabetic retinopathy complications, acute gallbladder disease, acute kidney injury from volume depletion, severe gastrointestinal reactions, hypersensitivity reactions, hypoglycemia when used with insulin or an insulin secretagogue, and pulmonary aspiration during general anesthesia or deep sedation
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The Increlex label explicitly contraindicates use in patients with active or suspected neoplasia and notes that active or suspected malignancy should prompt discontinuation
[55] established a rat kidney stone model by injecting glyoxalate and found that the mitochondria in rat RTECs became smaller and increased in membrane density, and the mitochondria were severely damaged
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As one expert says, Regular monitoring is essential to tailor Vitamin B12 therapy to individual patient needs and prevent over- or under-treatment. Response-Based Dosing Strategies We adjust Vitamin B12 doses based on how well the patient responds