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Pearsons correlations of normalized metabolite concentrations with disease activity and flow cytometry parameters were determined with MetaboAnalyst and Prism

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Oxidative stress caused by the overproduction of ROS and reactive nitrogen species, as well as changes in antioxidant enzyme activities, is implicated in NEO-induced injury to cellular molecules such as lipids, DNA, and proteins (Wang et al

Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)

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