doi: 10.3390/jcm12010145 Summary Keywords type 2 diabetes, chronic kidney disease, GLP-1 receptor agonists, semaglutide, glycosylated hemoglobin, weight loss, estimated glomerular filtration rate, urinary albumin-to-creatinine ratio Citation Garca de Lucas MD, Caballero I, Fernndez-Garca JC, Domnguez-Rodrguez M, Moreno-Moreno P, Jimnez-Milln A, Botana-Lpez M, Avils B, Merino-Torres JF, Soto A, Tejera C and Morales C (2023) Influence of chronic kidney disease and its severity on the efficacy of semaglutide in type 2 diabetes patients: a multicenter real-world study
Overall, the ADJUNCT programme demonstrated dose-dependent improvements in HbA 1c , a decrease in the daily insulin dose and a reduction in body weight with liraglutide compared with placebo
This fundamental difference in metabolism means they interact with fewer substances than small-molecule pharmaceuticals, but liver function still influences their clearance rate and tolerability
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