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Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha

Phil & Jamie Newcomb Phil and I first met in 2015 while working as nurses at Nebraska Medicine

GSPT1 degradation has emerged as a promising therapeutic strategy in oncology, but its essential role in normal cellular proliferation creates a narrow therapeutic window

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While many remain asymptomatic, others cause symptoms that disrupt daily life, including heavy menstrual bleeding, pelvic pain, and reproductive challenges

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction