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J Biol Chem (2004) 279(20):2137482.10.1074/jbc.M313522200 65 PeverelliEMantovaniGCalebiroDDoniABondioniSLaniaAet alThe third intracellular loop of the human somatostatin receptor 5 is crucial for arrestin binding and receptor internalization after somatostatin stimulation

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2.1 Hormonal factors Hormonal regulation is another important risk factor that plays a crucial role in breast cancer development, progression, and therapeutics ( Estrogen, a steroid hormone, is predominantly synthesized in ovaries until menopause and in adipose tissue post-menopause ( Hormonal exposure is further modulated by several factors, such as reproductive factors

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