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The GLP-1 and GIP receptors (GLP-1R and GIPR, respectively) are closely related members of family B or the secretin class of G protein-coupled receptors (GPCRs) and share a high degree of sequence homology (Mayo et al., 2003

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Treatment may involve improving adenosine or homocysteine handling, correcting zinc or magnesium, reducing oxidative stress, supporting mitochondrial energy, reviewing kidney function, improving buffering or addressing toxic and inflammatory burden