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However, as peptides break down, they can lose their structure and charge, leading to fragmentation and eventual loss of structural integrity

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Zhang J, Gao RF, Li J, Yu KD, Bi KX

CT-868 is a once-daily subcutaneous injectable, dual GLP-1/GIP receptor agonist being developed as an adjunct to insulin for the treatment of people with type 1 diabetes with overweight or obesity

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Therefore, all high-affinity binding ligands may not necessarily behave as GLP-1RAs and may potentially exhibit alternative functions, such as biased agonists, inverse agonists, and antagonists