Using chemogenetic, optogenetic, and viral tracing strategies to study how GLP-1 signals in the brain impact liver fibrosis and inflammation is an area of intense basic investigation
Improvement in insulin sensitivity The recent finding that GIP/GLP-1 receptor co-agonists like tirzepatide have superior efficacy compared to selective GLP-1 receptor agonists with respect to glycemic control as well as body weight has renewed interest in GIP [20], which previously was thought to be without any therapeutic potential
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L.BairdJ
Incretin-based therapies in MASLD/MASH: from GLP-1 receptor agonists to dual and triple agonists - mechanisms, clinical evidence, and therapeutic perspectives Hepatoma Res
inhibits the inflammatory cytokines IL-1, IL-6 and TNF-