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Therapeutic relevance of Tirzepatide Exploitation of GLP-1R and GIPR signaling has driven the development of dual-receptortargeted therapies

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Abbreviations BPH: Benign prostatic hyperplasia COS-ART: controlled ovarian stimulation/assisted reproductive technology CRPC: castration-resistant prostatic cancer COX-2: cyclooxygenase-2 EGF: Epidermal growth factor EMT: epithelial-to-mesenchymal transition FSH: follicle-stimulating hormone GH-RH: growth hormone-releasing hormone GRP: gastrin-releasing peptide GLY: glycine Gn-RH: Gonadotropin Releasing Hormone IGF-I: insulin-like growth factor-1 IVF-ET: in vitro fertilization and embryo transfer LEU: Leucine LH-RH: luteinizing hormone-releasing hormone MEF: mouse embryonic fibroblasts pGHRH-R: pituitary-GH-RH receptor PHE: phenylalanine PSA: prostate-specific antigen TRP: tryptophan TURP: transurethral resection of the prostate References Green, J

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