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The newer high-dose formulations finally make the oral route clinically relevant

While these medications don't directly alter thyroid hormone levels, significant weight loss can affect thyroid hormone requirements

Clinical trial data show that while fat mass accounts for the majority of weight loss, some lean mass reduction also occurs, which could potentially affect muscle function

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However, the FDA didnt add ileus (lack of proper intestinal movement or function) to Ozempics and Wegovys warning labels until 2023