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doi: 10.1034/j.1600-0749.2003.00029.x

These inhibitors result in increased ROS production from mitochondrial dysfunction, which contributes to the activation of the intracellular apoptotic pathway: Bax is translocated to the mitochondria and cytochrome c is released from the mitochondria into the cell matrix, triggering a caspase activation cascade, leading to cell death

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Plates were imaged using a CellInsight CX5 HCS platform (Thermo), and nuclei were identified as a readout of cell counts