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In addition, we did not observe compelling evidence for additional independent associations within the locus (Extended Data Fig

Betaine improved methylation capacity by increasing SAM/SAH ratio and normalized the gene expression of key enzymes accountable for one-carbon metabolism (e.g., BHMT, GNMT, and MGAT) associated with the regulation of fat metabolism in the liver ( Anomaly in gene expression in hepatocytes due to aberrant DNA methylation leads to the disorder of NAFLD

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