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The Pax7 transcription factor has been shown to be a key determinant of melanotroph identity, and it works by remodeling chromatin prior to Tpit expression, opening key areas of chromatin to allow Tpit and other transcription factors access to enhancers, resulting in melanotroph specification (13)

The cells from each group were cultured with vehicle or TGF-1 for 48 h

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42,43 Premature Sexual Maturation (Adrenarche) Girls who develop premature signs of puberty (before the age of eight) often have signs and symptoms similar to PCOS

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