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78,399 AZD3965 has already finished a Phase I/II clinical trial (NCT01791595) in patients with solid tumors diffuse large B-cell lymphoma, 76,79 which reveals its pharmacokinetic characteristics and adverse effects and suggests that AZD3965 is tolerated at doses that produce target engagement

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Another important mechanism involves oligoadenylate synthetase (OAS) pathway activated via dsRNA binding where US11 inhibits OAS activity, blocking RNase L, thereby aiding virus evade degradation while preserving infectivity (46)

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