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Myofibroblasts are the primary producers of collagen in tissue fibrosis 67,68 and play a role in tissue stiffness and the development of skin and joint contractures in SSc patients

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In three studies, several patients did not complete the study and had a high risk of bias in the incomplete outcome data domain (Reference Oner and Muderris11,Reference Kose and Naziroglu26,Reference Fulghesu, Ciampelli and Muzj29)