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Direct and indirect effects leading to sudden and catastrophic hemolytic anemia due to the direct toxic effects of copper on red blood cells has been described in the past [181,182,183,184,185,186,187,188,189,190]

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Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151

Discussion We provide, for the first time, direct evidence that only 38 days of extra oral glucose intakes four times a day can induce prediabetes