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Injectable administration, typically subcutaneous (just under the skin), bypasses the digestive system entirely

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The body does not mount the same defensive downregulation because the signaling patterns mimic endogenous processes

Kazak F, Yarim GF

Further research is needed to clarify regional differences within the DMH in the expression of GLP-1R and LepR, their upstream and downstream circuits, and how they can contribute to satiation or satiety in different feeding phases