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Description

these kinases are able to catalyze the phosphorylation of MAPKs, ERK1, and ERK2, thus rank-ordering the MAPK cascade from RAS, RAF, MEK, and finally to ERK [112, 113]

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ACC/AHA In 2019, the ACC and AHA published Guidelines on Primary Prevention of Cardiovascular Disease, suggesting that GLP-1 RA may help reduce CVD risk in patients with T2DM who require glucose-lowering medications despite lifestyle changes and use of metformin (Class 2a, Level of Evidence (LoE) B-R) [42]

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The absence of needle-related complications and a reduced likelihood of allergic reactions contribute to their safety profile

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