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If one is a downer and the other an upper, shouldnt their potential side effects be canceled out

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doi:10.1164/rccm.201510-1940OC Sawyer AM, Gooneratne NS, Marcus CL, et al

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The autosomal recessive Chediak-Higashi syndrome is characterized by eosinophilic, peroxidase-positive inclusion bodies in early leukocyte precursors, hemophagocytosis, increased susceptibility to infection, and increased incidence of an accelerated phase lymphohistiocytosis