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United States (FDA Classification) MOTSc is not approved by the FDA for human consumption Classified as a research-use-only (RUO) peptide Legal to purchase and possess for non-clinical, non-consumable use Not allowed to be sold as a dietary supplement or labeled for human injection This is the same legal structure shared by other research peptides like BPC157, TB500, and CJC1295

The SELECT trial demonstrated cardiovascular benefits independent of weight lossevidence that these agents have disease-modifying effects beyond BMI

10.1002/mus.26707 94 XieJ.FanX.SuY.ZhouH.CaoS.ZhuX.et al (2022)

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A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease