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Gastrointestinal adverse events, predominantly mild-to-moderate in severity, were more frequently reported with semaglutide compared to placebo (82.2% versus 53.9%)
Cardiovascular outcomes : Semaglutide has demonstrated significant cardiovascular benefits in large randomized controlled trials
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Estrogen deficiency can also impact appetite regulation, according to animal studies that have linked decreased estrogen with increased hunger and a reduction in spontaneous physical activity
A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration
Week 5 8: Initiate at 0.5 mg once weekly for 4 weeks
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