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the Epac-dependent signal induces explicitly expression of Mn-SOD, GPx-1, and catalase in cardiomyocytes and hepatocytes, reducing ROS and protecting cells from oxidative stress ( 6.2 GLP-1 role in metabolic stability GLP-1 plays a key role in maintaining metabolic stability, particularly in critical conditions such as sepsis, where the organism often enters a catabolic state with disturbed glycemic regulation

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PMID 9539826 Bowers CY, et al

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