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220,221 Licorice (Glycyrrhiza glabra) is contraindicated in pregnancy, as glycyrrhizin can elevate cortisol, increasing risks of preterm birth, hypertension, and developmental problems

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Tamaki et al., 2014)

First, it acted as a competitive inhibitor of 2-oxoglutarate-dependent dioxygenase (2-OGDD) function, and secondly, glutarate accumulation impaired activity of the pyruvate dehydrogenase complex (PDHc)

References Balkan J, Kanbali O, Hatipolu A, Kck M, Cevikba U, Ayka-Toker G, Uysal M (2002) Improving effect of dietary taurine supplementation on the oxidative stress and lipid levels in the plasma, liver and aorta of rabbits fed on a high-cholesterol diet