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Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity

J Appl Toxicol 2017;37:117481

The regulatory mechanisms of ferroptosis are not isolated but are intimately linked to the core metabolic activities of cells

Research indicates that Ex-4 can upregulate the expression of the glucocorticoid receptor (GR) inhibitory complex, promoting its binding with the GR, which reduces the binding of glucocorticoids to GR and their transport into the nucleus, thereby diminishing the negative effects of glucocorticoids on skeletal muscle (136)