For example, non-functional SNVs of CYP2C9*2 and CYP2C9*3 are associated with decreased VPA metabolism, so patients who are homozygous for CYP2C9*2 or CYP2C9*3 or who are heterozygous (CYP2C9*2/*3) have a PM phenotype and show decreased P-oxidation of VPA in liver microsomes [69]
O., Nekka, F., Mamputu, J
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In the other study, 71 individuals with abnormal glucose tolerance were enrolled (including individuals with prediabetes and 15 patients with early T2D) [56]
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