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Shifts to low growth temperatures create increased intracellular H 2 O 2 levels and induced expression of antioxidant genes implicated in glutathione synthesis [77, 78]

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Comparison with Other COMT Inhibitors Drug Site of Action Liver Toxicity Notes Entacapone Peripheral only Low Most commonly used Tolcapone Peripheral + CNS High Requires liver monitoring Opicapone Peripheral Low Long-acting, once daily --- 11

READ MORE: Eye nutrition news Shereen Jegtvig, CNS, also contributed to this article.

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However, the same mechanisms that reduce someone's appetite can also create nutritional challenges