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Nevertheless, studies in human subjects with type 2 diabetes surprisingly showed well-preserved insulinotropic activity of both GLP-1 [736 amide] [5] and GLP-1 [736] that was accompanied by a short-term reduction in plasma glucose in the normal fasting range in patients previously characterized by persistent hyperglycemia [6,7]

However, we often wonder, is this purely from weight loss and glucose control, or is there a more direct effect on the heart

Despite these technical advances, the researchers have acknowledged important limitations

doi: 10.1192/bjp.148.1.87 20 BullockB

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