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Tirzepatide uses a similar dose range to retatrutide but with different escalation steps

Nausea, vomiting, diarrhea, and constipation are the most frequently reported issues with both peptides

doi: 10.1038/nrm1960 57 AkabasMH

GPx7 likes to interact with the domain of PDI, and intramolecular cooperation between the two redox-active sites of PDI increases the activity of the Ero1/GPx7/PDI triplet, thereby promoting protein folding mechanisms (Wang et al., 2014) (Figure 6)

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