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The long-term weight loss effect of GLP-1RAs has also been validated in a recent large-scale clinical trial, which reported a weight loss up to 20.9% after 72-week treatment of tirzepatide [22]

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Within six weeks, he lost nearly three inches off his waist, reported more consistent daily energy, and noticed his endurance improving in workouts

The trials assessed participants using the apnea-hypopnea index (AHI), which measures the frequency of breathing interruptions during sleep

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Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M et al (2012) Human gut microbiome viewed across age and geography