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SURMOUNT-1 (NEJM, 2022) the Tirzepatide Phase 3 trial enrolled 2,539 participants

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Chronic drug exposure can cause adverse changes in neural networks, particularly affecting synaptic plasticity in the mesocortical limbic DA system, which may contribute to compulsive drug behavior

It works through two complementary mechanismsregulating both appetite (GLP-1) and metabolic efficiency (GIP)

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Reconstitution Reconstitute only under an approved laboratory protocol using the diluent and final concentration specified for the study