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Excessive ROS production can lead to cellular damage by increasing the formation of AGEs, its receptor (RAGE), protein kinase C (PKC), and NF-B

However, such a wide range of even opposite disturbances that can be all attenuated/counteracted, given a general counteracting potential, can match with the original cytoprotection concept perception holding the equal cell protection (necrosis prevention) against a variety of different agents (originally used absolute alcohol, boiling water, strong base, and strong acid claimed for common endogenous mechanisms)

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NAD+, or nicotinamide adenine dinucleotide, is a vital coenzyme in redox reactions and plays an indispensable role in energy production at the cellular level