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After adding NAC a GSH precursor the authors observed a significant decrease in HO-1 expression compared to HGF challenged only with nicotine

Since GSH is not carried inside the cell, exogenously administered GSH is most likely to act by increasing plasma GSH levels reducing luminal oxidative stress and increasing NO bioavailability in patients with endothelial dysfunction (220)

ZorogluSSArmutcuFOzenSGurelASivasliEYetkinOet al

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