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Because non-aspirin NSAIDs bind reversibly, their effect is relatively transient, and will not provide the same long-term benefit to suppress platelet activity as aspirin

Chen PY-T, Adak S, Chekan JR, Liscombe DK, Miyanaga A, Bernhardt P, et al

The mechanisms linking obesity and MS progression involve chronic inflammation

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The STEP clinical program demonstrated that participants lost an average of 1015% of their body weight over 68 weeks, with meaningful progress appearing after the first full month of treatment