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When the HOPE-2 trial (51), and other major trials such as VISP and VITATOPS (52), were re-analyzed, specific subgroups were identified that were most likely to benefit from B vitamin supplementation in reducing stroke risk, including (1) adults less than 69 years of age, (2) those not exposed to folic acid fortification, (3) those with elevated homocysteine or cholesterol, and (4) those who were not taking anti-platelet or lipid-lowering drugs

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Haden ST, Glowacki J et al