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Abdominal fat loss, as well as sustained reductions of fasting insulin levels and markers of IR, have also been shown in patients with T2D and individuals with overweight/obesity and/or prediabetes after their administration [5860]

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involved cyclizing carnitine to -hydroxy--butyrolactone, then acetylating to form -acetoxy--butyrolactone, preserving the chiral center and enhancing detection sensitivity (Abreht et al., 2014)