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[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness

[12] [13] Whilst personal possession for self-use is not straightforwardly criminalised, individuals should be aware of the legal and safety landscape before obtaining such substances

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

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