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Thus, there could be unescapable risks of unanticipated adverse effects due to pleiotropic effects [1]

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The expression of constitutively active, standard immunotherapy treatment (trastuzumab and pertuzumab) resistant, truncated p95-ErbB2 in breast cancer cells activates macropinocytosis leading to increased uptake of extracellular cholesterol

In rare patients, Vit B12 deficiency may result in peripheral neuropathy and megaloblastic anemia

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doi: 10.4103/NRR.NRR-D-24-00241 186 ChenBChenZLiuMGaoXChengYWeiYet al