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Akkermansia is a beneficial gut bacterium associated with gut barrier integrity and metabolic signaling

Further docking studies with aldose reductase, DPP-4, PPAR, and glucosidase revealed that chalcones 13, 16, 17, 18, and 19 (Figure 4) inhibited DPP-4 activity more effectively than others

It has been used clinically in other countries (including Italy, China, and Thailand) for viral infections, hepatitis, and immune disorders for decades

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It is likely that problematic food and drug cravings share a similar biological basis, and next-generation medicines may be more powerful or more targeted to one or the other